Bacteria can be programmed to produce drugs efficiently
Researchers found a new
approach to manage the distribution of essential resources in modified cells by
advancing the capacity of synthetically programming cells to fight against
disease and bring novel drugs.
They discovered a new
method to control ribosomes distribution; Microscopic 'factories'-which build
proteins inside the cell to maintain the cell alive and functional for both synthetic
circuit and host cell.
To improve the cell,
Synthetic circuitry might be included to perform specially made functions which
offer the new promise for future healthcare also pharmaceuticals sciences.
A cell has only limited
amount of ribosomes, the host cell where the circuitry is inserted and the
synthetic circuit will compete for this limited pool of resources. To survive, multiply
and thrive it is necessary to provide enough ribosomes for both or else the
circuit will fail or the cell will die.
The researchers have developed and
demonstrated a unique system using the engineering principal of a feedback control
loop system through which ribosomes can be distributed dynamically so that more
ribosomes will be allocated to synthetic circuit for proper function and less will
be allocated for the host cell.
Ribosomes live inside cells, and assemble
proteins whilst required for a cellular function. When a cell requires protein,
the nucleus creates mRNA also sent that to the ribosomes. Later it synthesise
the essential proteins via bonding the appropriate amino acids together in a
chain.
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Gulf Congress on Pharmacy and Pharmaceutical Sciences
scheduled on September 17-18, 2018 Abu Dhabi, UAE is a international stage to
talk about the innovative researches and advancements in the Pharmaceutical
field. It will be a brilliant chance to meet renowned personalities in the
fields of pharmaceutics and to gain knowledge of the most recent innovative
advancements.
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