Therapeutic Discovery team developed the first small molecule drug, IACS-10759, from the concept to clinical trial including IACS and the CCCT. Therapeutic Discovery is a group of clinicians, researchers,
An emerging hallmark of tumor biology known as metabolic reprogramming where cancer cells developed on two metabolic processes, glycolysis and oxidative phosphorylation (OXPHOS), for their growth and survival.
Extensive efforts have focused on therapeutic targeting of glycolysis which stimulated the discovery and development of IACS-10759 which is a potent and selective inhibitor of OXPHOS. This clinical trial was made possible by more than 25 scientists across Therapeutics Discovery.
In pre-clinical studies, IACS-10759 was calculated for treating lung cancers in the SMARCA4 gene which provide tumors sensitive to the drug. SMARCA4 is a component of SWI/SNF, a chromatin modeling complex, plays an essential role in gene expression.
The topic is related to drug discovery which is explained in Pharmacy and Pharmaceutical conference which will be held on Sept 24-25, 2018 in Abu Dhabi, UAE with the theme of Global Innovations and Recent Advancements in Pharmaceutical Sciences. For knowing about drug discovery, drug development, drug safety etc follow the link below:
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